Physician consult included · Free shipping nationwide · Medical follow-up ·

Three PeptoClinic Retatrutide vials labelled for appetite control, satiety and metabolism, beside a woman in sportswear

Retatrutide 10 mg vial beside before and after photos, with three notes: it reduces appetite, prolongs satiety and supports weight loss through GLP-1, GIP and glucagon

Your journey week by week: in week 1 you begin to adjust, in week 2 the routine gets easier, in week 4 changes begin to appear and in week 8 progress becomes more noticeable

Nayana Ambardekar, MD, holding a PeptoClinic Retatrutide vial, beside a summary of the receptors the compound acts on and a before and after photo

New peptide technology

Lose the fat without losing muscle

Retatrutide works on three hormone pathways at once: it regulates appetite, fills you up sooner, and makes what you lose fat rather than muscle. With medical follow-up from start to finish.

Less fat — It works on three hormone pathways, not one.
Appetite under control — You eat less without fighting it: you fill up sooner and the cravings ease off.
Muscle held on to — What you lose is fat, not lean muscle.
A physician behind it — A licensed physician reviews your case before you start.

10 mg vial

US$235 US$285 Save US$50 · 18%

This is a one-time payment, not a subscription. Free shipping nationwide.

Physician consult included · Ships in 24 to 48 business hours

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What people ask us most

How is it taken?

It is a subcutaneous injection once a week, with an insulin syringe. The vial arrives lyophilised and you reconstitute it with the bacteriostatic water that comes included; the step by step is on the site and we send it to you as well. It takes under a minute and you do it at home.

How long does a vial last me?

It depends on your weight, because the dose is worked out from it. A 10 mg vial lasts between six and seven weeks on the conservative start, and around four if you end up on the higher dose. Once you send us your weight and height we tell you exactly how long yours will last.

Is it a one-time payment or am I charged every month?

Whichever you prefer — you choose at checkout. The one-month plan is a single payment: you are charged once, nothing renews and there is nothing to cancel. The longer plans are billed month by month, and the longer the plan the lower the monthly rate, so paying monthly comes out cheaper per month than buying one month at a time. Either way you are told how many charges there will be before you confirm, and they stop on their own when the plan ends.

Does it have side effects?

In most cases the treatment is well tolerated, especially starting on a low dose and going up gradually. Digestive complaints — nausea, vomiting, diarrhoea — are not common among our patients, and they show up more when the dose goes up too fast or with no follow-up. That is why we start gradually and follow up throughout the treatment.

How can I pay?

Credit or debit card at checkout. The consult is included in the price and is refunded if you are not approved.

How does the order arrive?

Free shipping nationwide, within 24 to 48 business hours of the payment clearing. It travels in a sealed parcel with nothing on the outside saying what is inside.

Do I get support during the treatment?

Yes. Our support does not end once you have bought. We stay with you through the whole treatment so you can settle any question that comes up along the way.

You can text us 24 hours a day and ask about dosing, injecting, how to use the product or anything else that comes up. Our team is there to point you in the right direction and answer quickly when you need it.

If this is where you are, it is for you

A woman sitting in front of the open fridge at night, with food on the table

Hunger between meals gets the better of you and the whole day's effort falls apart at night.
You have tried diets and dropped them because at your pace they were impossible to keep up.

A woman trying to do up the button on a pair of jeans

You lose weight and put it back on, the same thing every time, and you have run out of ideas.
After 40 your body changed: you eat the same as before and the weight goes up anyway.

A tired woman in front of a laptop, resting her head on her hand

When you do lose weight you lose muscle with it and end up soft instead of firm.

The problem is hardly ever willpower. It is that appetite and fullness are run by a hormone, and willpower does not beat a hormone.

Now picture feeling in control again…

Feeling satisfied on less food, thinking about eating less during the day, and being able to keep your habits going more easily. Support built so that losing weight feels simpler and more orderly.

22.5%

average weight loss recorded in clinical trials

In clinical trials, patients treated with retatrutide — the peptide that regulates appetite and blood sugar — lost on average up to 22.5% of their body weight without giving up muscle.

This is what the literature on the compound suggests, not a promise. A licensed physician reviews your case before approving treatment.

How retatrutide works in weight control

Less appetite

It acts mainly on the GLP-1 and GIP receptors, helping bring hunger down through the day and making portions and intake easier to control.

More fullness

GLP-1 activation supports a longer-lasting feeling of fullness after eating, helping make an orderly way of eating easier to keep to.

Fewer cravings

Its action on the GLP-1 and GIP pathways can reduce the urge to eat constantly and help you get more control over cravings and daily intake.

Support for weight loss

Its triple agonism on GLP-1, GIP and glucagon combines effects on fullness, appetite and energy expenditure — mechanisms being studied for their impact on weight loss.

Why this one and not another

Three pathways, not one

Retatrutide is a step up from Ozempic-type medicines: instead of working on a single hormone pathway, it works on three — GLP-1, GIP and glucagon. It brings appetite down and makes you fill up sooner.

A gradual start

You start on a low dose and go up bit by bit. That is what makes it well tolerated in most cases and keeps digestive complaints uncommon.

A physician sets the dose

Your weight and your height decide what you start on and how long the vial lasts you. You do not pick it off a list: a licensed physician reviews it before you start.

Every lot, analysed

Our laboratory makes it and an independent laboratory analyses it. Every lot ships with its certificate, and the certificate can be opened and read right here below.

Jennifer lost 26 pounds without dieting

Jennifer C., Dentist.

What people who have done it say

Five people on what they struggled with and what changed. The words are their own.

Verified customer

I am back in clothes I had put away

I had been trying to lose weight for a long time, but I always ended up giving up. The hardest part for me was controlling portions and cravings. With the support I started to feel that keeping to a routine was much easier. Over time the weight came down and I ended up wearing clothes I had had put away for years.

Laura Bennett · age 48 Using peptides for 2 months

Verified customer

I stopped thinking about food all day

My problem was never not knowing what to eat. I knew perfectly well what I had to do, but by the afternoon I would end up picking at whatever was around. The first thing I noticed was that eating normal portions became much easier. Then the scale started to move as well, and that motivated me a great deal more.

Caroline Foster · age 42 Using peptides for 3 months

Verified customer

I thought I was going to quit again

I had tried diets a thousand times and I always lasted two or three weeks. This time I went about it differently and made changes little by little. When I started to see the weight come down without feeling that I was constantly on a diet, I decided to carry on. The best part was getting my consistency back.

Diane Sullivan · age 51 Using peptides for 2 months

Verified customer

I feel comfortable in a T-shirt again

After 40 I started putting on weight, and there came a point where I avoided certain T-shirts because I did not like how they looked on me. I started the process without expecting a huge change, but little by little I noticed a difference at the waist and in my clothes. That is what motivated me most.

Greg Harrison · age 46 Using peptides for 2 months

Verified customer

I noticed the difference in my clothes first

At first I was weighing myself every day and it was driving me mad. Then I stopped. One day I put on a pair of jeans that used to be tight on me and they were loose. That was when it hit me how much had changed.

Sophie Reynolds · age 39 Using peptides for 4 months

What makes PeptoClinic different?

It is not only about the product. We put transparency, traceability and support first, all the way through.

PeptoClinic Buying with no support

Lab analyses available to verify quality and composition*

Lot information and product traceability*

Clear storage and reconstitution guides

Support and follow-up through the process

* The published lab reports are at peptoclinic.com/en/quality/. The report for the lot you receive is available on request.

Who reviews it

Professional medical oversight

Guidance and follow-up are handled by a licensed physician, who assesses each case individually, answers your questions and supports the process responsibly. Because when it comes to your health, clear information and professional follow-up are what matter.

Nayana Ambardekar, MD

Board-certified physician · Emory University

Independently tested

Read the lab report before you read our copy

Anyone can write “≥99% purity”. These are the analyses behind that number: a named laboratory, a dated report and a link that leaves this site for them.

98.469% — lowest we have published · 6 Reports · Janoshik Analytical · Kovera Labs

See every report

Every lot with a certificate

Secure checkout

Free shipping nationwide

Medical follow-up

The PeptoClinic community

Kristen Walker

I'd been trying to lose weight for a long time and I always ended up giving up. The hardest part for me was the hunger and picking at things all day. About a month and a bit ago I started with PeptoClinic and honestly it's been helping me a lot, I eat smaller amounts and I'm not thinking about food all the time. very happy so far

118 12 comments

Amber Collins

I tried loads of things before and could never keep any of it up haha. I started out with my doubts but within a few weeks I was already noticing a difference, especially in how clothes fit and with the anxiety around food. Also every time I asked something they got back to me straight away

87 6 comments

Michelle Barnes

After 40 it got harder and harder to shift the extra pounds I was carrying. I started without much expectation honestly and bit by bit I started seeing changes. It wasn't overnight but I feel lighter and much more in control around meals. it really worked for me. LADIES I RECOMMEND THE RETRATUIDE!

142 18 comments

Customer reviews

4.9 1,235+ reviews

(1,130)
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Heather M. Verified purchase

Aug 19, 2026

It arrived the next day and well packed, with the water and the syringes separate. I messaged with a question about the dose and they answered right away, they're not the sort to leave you hanging. I've already ordered the second one.
Rachel S. Verified purchase

Aug 11, 2026

I'm 54 and with the menopause everything that used to work for me had stopped working. This is the first thing that's given me a real change. It isn't magic, you have to back it up with food and walking, but you notice it.
Jessica Verified purchase

Jul 22, 2026

I bought it sceptical, I'll say that. It came with the lot analysis and the number matched the one on the site. I've now recommended it to my sister who's been struggling with this for years.
Melissa R. Verified purchase

Sep 1, 2026

The biggest change for me is that I stopped thinking about food all day. I have a normal dinner and I don't end up picking at things at night, which was my worst time. My clothes started fitting differently without me doing anything odd.
Brandon K. Verified purchase

Aug 28, 2026

The injecting part put me off and honestly you don't feel a thing, the needle is tiny. I prepared it following the step by step on the site and in five minutes it was done. It's just another Sunday night routine now.
Danielle W. Verified purchase

Aug 24, 2026

It works, no argument there, the anxiety around food went away pretty fast. The only thing is that the first two weeks it sat heavy in my stomach if I ate a lot at once, after that it settled on its own. I'm giving it 4 just for that start.
Tyler B. Verified purchase

Aug 15, 2026

I've got results, that I'll give you. But I think it's expensive for what one vial gets you, you need to do the maths before you start. I went ahead anyway because on its own it wasn't adding up for me.
Ashley D. Verified purchase

Aug 6, 2026

Very happy with everything. I'd have liked a printed set of instructions in the box for anyone who isn't one for watching videos, my mum would have appreciated it. Other than that, faultless.
Kevin T. Verified purchase

Jul 30, 2026

Before selling me anything the physician asked what I was taking and how my blood pressure was, and only then told me what dose to start on. That reassured me, it's not a case of they charge you and goodbye.
Ryan

Jul 14, 2026

all good, got here fast and it works

Reviews from people who bought, unedited. Results vary from person to person. The photos alongside some reviews are illustrative.